All Greater Good Foundation
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Orphan Disease

The Guthy-Jackson Charitable Foundation

Neuromyelitis Optica (NMO) Spectrum Disease


The Guthy-Jackson Charitable Foundation


The All Greater Good Foundation (All Greater Good), on behalf of The Guthy-Jackson Charitable Foundation, is dedicated to identifying appropriate, cutting-edge research and practice, cultivating a collaborative research environment, and being recognized as a credible resource on Neuromyelitis Optica (NMO) Spectrum Disease, (Devic’s Disease), a rare misunderstood and often misdiagnosed disease.

In its current work for The Guthy-Jackson Charitable Foundation, All Greater Good has formed a scientific and medical advisory board to provide oversight for projects and outcomes; identified basic science research centers that may apply for research funding; evaluated clinical centers of excellence; and solicited proposals to fund appropriate basic science and clinical research. All Greater Good works toward an ultimate goal of fostering collaboration between national and international NMO-dedicated research and clinical centers dedicated to the study of neuroimmunology.

Ultimate Foundation goals include:

        - Establishing a centralized, functional patient registry, including cataloging of serum, tissue, and DNA
           samples.

        - Understanding the epidemiology of NMO Spectrum Disease, including incidence, prevalence, and
           clinical course; developing clinical tools to objectively follow the disease course in individualized
           patients.

        - Supporting an annual conference to convene researchers and clinicians, thereby providing a platform
           for the presentation of research outcomes and new discoveries.

        - Studying alternative approaches in disease management.

        - Design and develop public information tools to heighten awareness.

        - Understandings of NMO Spectrum Disease.

        - Understanding the role of lifestyle and stress on disease progression.

We invite you to visit The Guthy-Jackson Charitable Foundation’s website by clicking here to learn more about what the Foundation is doing to help find solutions for NMO.



Centers we work with for NMO research:



Mayo Clinic
The Mayo NMO Consortium has coalesced over the past decade as an interactive team of clinical and basic investigators with a common interest in neurological autoimmunity and neuroprotection. The goals of the Mayo NMO Consortium are to:

 

        - Uncover the genetic and biological factors that lead to development of NMO
        - Define the pathophysiologic mechanisms that are unique to NMO
        - Produce animal models of the disease
        - Develop novel and specific therapeutics based on our discoveries in pathophysiology

The Mayo Team members

        - Vanda Lennon, M.D., Ph.D., Professor of Immunology and Neurology
        - Claudia Lucchinetti, M.D., Professor of Neurology, Mayo Clinic College of Medicine
        - Sean Pittock, M.D., Assistant Professor of Neurology; Associate Director, Neuroimmunology Laboratory
        - Brian Weinshenker, M.D., Professor of Neurology, Mayo Clinic College of Medicine

Visit the Mayo Clinic Website.
 

 

The Scripps Research Institute

The focus of TSRI will be to develop mouse models of AQP4 autoimmunity, drawing from their expertise in autoimmune diseases and mechanisms by which immunological tolerance to self-antigens can be broken. Availability of such models will permit to directly study humoral and cellular contributions to this disease, develop monoclonal antibodies, T cell hybridomas and transgenic mice, and assess novel immunosuppressive therapies for NMO.


The Scripps NMO Team

 

        - Roberto Baccala, Ph.D., Associate Professor, Department of Immunology and Microbial Science

        - Argyrios N. Theofilopoulos, M.D., Professor and Chairman, Department of Immunology and Microbial           Science

 

Click here to view Dr. Baccala at The Scripps Research Institute
Click here to view  Dr. Theofilopoulos at The Scripps Research Institute

 


Stanford University


Steinman Lab

The long range aim of the Stanford team in NMO research is to develop a powerful, safe, specific tolerizing immune therapy aimed at eliminating the main immune responses in neuromyelitis optica, while leaving the rest of the immune system intact.

The Stanford University NMO Team


        - May Han, M.D., Senior Fellow in Neuroimmunology; Acting Assistant Professor of Neurology and
           Neurological Sciences
        - William R. Robinson, M.D., Ph.D., Assistant Professor of Medicine
        - Lawrence Steinman, M.D., George A. Zimmerman Prof. of Neurology, Pediatrics and Genetics, Chair
           Interdepartmental Program in Immunology

Visit the Steinman Lab Website.
 

University of California, San Francisco

Verkman Laboratory

NMO research will address basic questions about the role of AQP4 autoantibodies in NMO at the AQP4 molecular level, astrocyte cell level and whole organism level.

Verkman Lab Team

        - Alan S. Verkman, M.D. Ph.D., Professor of Medicine and Physiology, UCSF
        - Marios C. Papadopoulos, M.D. FRCS(SN), Senior Lecturer in Neurosurgery, St. George's, University of            London (co-principal investigator
        - Jonathan Crane, Ph.D., Post-doctoral Fellow, UCSF
        - Lukmanee Tradtrantip, Ph.D., Post-doctoral Fellow, UCSF
        - Samira Saadoun, Ph.D., Post-doctoral Fellow, St. George's, University of London
        - Hua Zhang, Ph.D., Post-doctoral Fellow, UCSF

Visit the Verkman Laboratory Website.
 

Zamvil Laboratory

The Zamvil Lab hypothesizes that AQP4-specific T cells may be activated and/or expanded in NMO patients.

Zamvil Lab Team


        - Scott S. Zamvil, M.D., Ph.D., Principal Investigator
        - Patricia A. Nelson, Ph.D., Specialist
        - Collin M. Spencer, Specialist
        - Juan Carlos Patarroyo, Specialist

Visit the Zamvil Laboratory Website.

All Greater Good Foundation
2009 NMO Roundtable Conference Photos

Scientists discuss NMO at the 2009 NMO Roundtable ConferenceGroup discussion about NMO at the 2009 NMO Roundtable Conference
Group discussion at the 2009 NMO Roundtable ConferenceA researcher takes notes at the 2009 NMO Roundtable Conference
A scientist asks a question at the 2009 NMO Roundtable ConferenceTaking notes at the 2009 NMO Roundtable Conference